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Two trials used cholecalciferol (vitamin D3), and one trial used a synthetic analog of active vitamin D called eldecalcitol, which is a prescription drug for osteoporosis in Japan

The donation of SAM's methyl group reduces it to SAM-e (S-adenosylmethionine), which reforms homocysteine, and the cycle begins again

The Lancet Frias JP, et al

The signaling system controlling this balance is remarkably complex

Free Radic Biol Med 2008

This approach selectively targets pigmentation without causing thermal damage to surround tissues, minimizing the risk of inflammation and post-inflammatory hyperpigmentation