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Thus, survival and normal functionality of cells are critically dependent on oxygen delivery performed by the heme-containing hemoglobin protein, which is the most abundant protein in erythrocytes [43]
While a vast body of evidence demonstrates a correlation between elevated pro-inflammatory cytokines (e.g., IL-6, TNF-) and depressive severity in IBD patients, the causal impact of pharmacological neutralization of these mediators is still being delineated through rigorous clinical trials (Luo et al., 2025)
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Indeed, the liver has been reported to need a maximal synthesis of GSH for detoxifying exogenous xenobiotics, such as acetaminophen 75,76
