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Of particular note, the NAION case seen on separate occasions was challenged then rechallenged with semaglutide, supporting a direct toxic reaction to the drug

Therefore, early detection and follow-up requirements for adverse reactions should vary depending on the affected systems

doi: 10.1038/nn.3413 190 SutcigilL.OktenliC.MusabakU.BozkurtA.CanseverA.UzunO.et al

Supplementary Figure 8 (A, B) Cumulative data showing relative concentrations of decreased metabolites in the R vs A group

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Whats particularly relevant for perimenopausal women is how these triggers may become more potent during hormonal fluctuations