NICE guidance recommends GLP-1 receptor agonists for type 2 diabetes under specific circumstances, typically when metformin and other agents have not achieved adequate glycaemic control, and often with particular BMI thresholds or when insulin would otherwise be considered
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Among the 281 samples not classified by core region, 1 sample was classified as subtype 1c, 9 as 1 h, 22 as 1 l, 2 as 2a, 70 as 4f, 1 as 4o, 13 as 4p and 7 as 4 t by NS5B region (Table 5)
E.ZiebaA.et al (2016)
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When used with insulin or sulfonylureas, dose reductions of these medications are typically necessary to prevent hypoglycemia, with insulin doses often reduced by 1020% at initiation