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Cardiovascular Benefits of GLP-1 Medications Multiple large-scale cardiovascular outcome trials (CVOTs) have demonstrated that certain GLP-1 drugs reduce the risk of major adverse cardiac events (MACE) in high-risk patients: The SELECT trial result is particularly significant: it was the first to show cardiovascular protection from a weight loss drug in patients without diabetes expanding the potential use of semaglutide far beyond its original indication

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It also encouraged patients to complain to the FDA about how difficult the situation is, including a link out to leave the regulators a comment

Wilcoxon Signed-Rank Test was used to compare RSSv1 and MLI