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These include the hypothalamus, VTA, and nucleus accumbens

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The current findings further corroborate the well-established renoprotective role of melatonin across diverse experimental models of membranous nephropathy, lupus nephritis, hypertensive nephrosclerosis, acute ischemic kidney injury, unilateral ureteral obstruction-induced renal injury, treatment-induced nephrotoxicity, and contrast-induced AKI (Stacchiotti et al., 2002