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Obesity and weight loss in idiopathic intracranial hypertension: a narrative review, 2017

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The bupropion component carries an FDA boxed warning for increased suicidal ideation in young adults, similar to other antidepressants

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A patient can finish a course of GLP-1 treatment significantly lighter and simultaneously in a weaker metabolic position than when they started if muscle preservation was not part of the plan. This is the mechanism behind what clinicians commonly observe in weight cycling