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This depends on the cause

Clinical studies have observed that patients can lose 15% to 20% of their body weight over approximately 72 weeks, a significant advantage over other weight loss interventions like Ozempic

For patients at moderate risk of rhabdomyolysis who are at low risk of fluid overload, consider empiric IV fluid administration (e.g., D5LR at 150 ml/hr)

Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, et al

The clinical recommendations here are more concrete than anything I've seen from a professional body

These changes are related to the sodium-retaining properties of GH and IGF-1 via ENaC in the renal distal tubules ( vide supra ) and can be reversed if patients undergo effective treatment of the GH-producing tumor [100]