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Description

The cryo-EM maps allowed us to build an unambiguous model for most regions of the complexes except for the flexible -helical domain (AHD) of G and the stalk between transmembrane helice 1 (TM1) and extracellular domain (ECD), which were poorly resolved in most cryo-EM structures of GPCRG s complex (Supplementary Fig

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But now, imagine that signal turned down

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References Abramczyk R et al (2020) Diabetes and psoriasis: different sides of the same prism

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The result is a systems-level approach to digestive health, with butyrate at the center as the key metabolite.

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