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Changes in dietary intake, weight loss, or gastrointestinal symptoms associated with semaglutide initiation could indirectly influence warfarin's anticoagulant effect through alterations in vitamin K intake or absorption

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Despite the different doses of semaglutide and tirzepatide and timepoints studied, the results of SURMOUNT-5 and the Truveta Research study were consistent, namely that tirzepatide-based medications performed better than semaglutide-based medications: SURMOUNT-5 study : At 72 weeks, weight loss was 20.2% for Zepbound (tirzepatide AOM) compared to 13.7% for Wegovy (semaglutide AOM)

It can also serve as supportive therapy in cases of inappetence