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References Gisondi P, Bellinato F, Targher G, Idolazzi L, Girolomoni G

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10.1016/j.schres.2006.06.012 Schizophr

SIRT1 also plays a pivotal role in reducing inflammation by deacetylating the p65 subunit of NF-B, thereby reducing the transcription of pro-inflammatory genes, offering a potential solution for inflammatory conditions (177)

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Since thyroid hormone uptake in the pituitary is relatively unaffected by outside factors, the presence of intracellular hypothyroidism is not reflected by TSH testing, which is why TSH is a poor marker for cellular thyroid function in any tissue other than the pituitary