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Analysis of FAERS data from 2004 to 2020 revealed significant associations between GLP-1 RA and various neoplasms, notably medullary thyroid cancer (PRR, 27.43), papillary thyroid cancer (PRR, 8.68), malignant pancreatic neoplasms (PRR, 9.86), and pancreatic neuroendocrine neoplasms (PRR, 2.86) [52]

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These adverse effectsincluding nausea, vomiting, diarrhoea, constipation, and abdominal discomfortare dose-dependent and represent the most frequent reason for treatment discontinuation

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Emerging evidence positions GLP-1RAs as a transformative candidate for ocular therapeutics