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10.1016/j.bioactmat.2021.03.023 Bioactive Mater

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Retinoid mechanisms differ fundamentally from GHK-Cu by directly binding nuclear receptors controlling gene expression and cell turnover rather than providing enzymatic cofactors supporting natural processes, creating stronger effects but also more pronounced dependency where discontinuation often triggers rebound effects

The freeze-dried sample was dissolved in deuterium oxide (D 2 O) for 1 H NMR