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Smaller molecules that can easily access the radical site tend to have higher antioxidant capacity, while larger compounds may react more slowly or remain inert

It must be reminded that in our experience, IGF-1 treatment does not only raise IGF-1 plasma levels, but also stimulates tissues to synthesise their own IGF-1 by a mechanism still not uncovered, aiming these mechanisms of central stimulation of peripheral improvement

Weekley and Harris, 2013)

185 In a clinical pilot trial on 14 advanced cancer patients, combined insulin/glucose infusions were therefore started at most 18 h before the administration of methotrexate/5FU

A pilot study of all-trans-retinoic acid for the treatment of human emphysema

"Alpha-lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects." J Lipid Res