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Multiple brain cell types have been identified to enter cellular senescence with advanced aging and/or AD including astrocytes (38), microglia (40), OPCs (37), neurons (35, 39), endothelial cells (41), and smooth muscle vascular cells (42)
Negative evidence: A study in Indonesian individuals showed that supplementation with glutathione combined with vitamin C, alpha-lipoic acid, and zinc did not significantly lighten skin compared to placebo (Sitohang et al., J Clin Aesthet Dermatol, 2021) [63]
Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis (245)
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The treatment is almost painless except for the possibility of discomfort or headaches
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