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The objective of this review is to summarise the systemic actions of the incretins and the metabolic hormones produced by the pancreatic islets and their interactions with their respective receptors

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Side effects were minor, including nausea and facial flushing

Many patients with digestive conditions, low stomach acid, or gut dysbiosis also have impaired oral absorption that IV therapy bypasses entirely

While there are limitations, the promise of improved diabetes management, cardiovascular benefits, and new formulations places GLP-1 agonists at the forefront of diabetes care