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This essential coenzyme of ThDP-dependent enzymes is absolutely necessary not only for oxidative glucose metabolism, but also for coupling metabolic pathways of carbohydrates and amino acids, as well as for controlling de novo synthesis of major neurotransmitters, ACh and glutamate, from glucose

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These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia

Candidate docking or undocking events were found manually as granules that approached the TIRF field with an axial component and became laterally confined for at least two frames