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Sections were produced with an ultramicrotome UC6 (Leica Microsystems, Vienna, Austria), with a thickness of 7080 nm

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For functional analysis, the identified DEGs were subjected to gene set enrichment analysis (GSEA) using the MSigDB v2023.2.Hs collection

Early response is one of the strongest predictors of long-term success on GLP-1 therapy patients who see results in the first month stay engaged and stay on treatment

In human studies, pramlintide, acting as an amylin analog, slows gastric emptying, reduces the postprandial rise in plasma glucagon, and modulates satiety leading to decreased caloric intake

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