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PMID 40465419 characterised hexarelin as the primary hepatic metabolite of alexamorelin a structurally related compound from which hexarelin is generated by carboxypeptidase-mediated C-terminal alanine cleavage (alexamorelin signal decreased approximately 150-fold within 3 hours of hepatocyte incubation)

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Lean male C57BL/6 mice (8-16 weeks of age, body weight 25-30 g, purchased from Charles River) were maintained at 21-23C and light-dark cycles (12:12 hour schedule, lights on at 07:00)

PMCID: PMC8789089

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