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doi: 10.1016/j.fertnstert.2016.09.014 152 JrgensenHHillASBesteMTKumarMPChiswickEFedorcsakPet al

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The impairment or absence of GLP-1 effects in type 2 diabetes suggests a role in its pathogenesis

PMID: 140 ZhangYGuoKLeBlancRELohDSchwartzGJYuYHet al

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Rather than sitting on the filtering cells of the nephron, the receptor is found mainly in the smooth muscle of the renal vasculature, so much of GLP-1s renal effect is hemodynamic and hormonal rather than a direct action on kidney tubules