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Mechanistically, TMAO impairs cardiomyocyte contractile function and disrupts intracellular calcium handlingprimarily through induction of mitochondrial dysfunction that reduces cellular energy production ( Gut microbiota dysbiosis and increased intestinal permeability drive chronic inflammation, which directly activates the Nuclear Factor Kappa-B (NF-B) signaling pathway ( 2 O 2 ) overproduction

Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus

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deficient glutamate clearance is the primary element of several severe neurodegenerative diseases such as for example in ALS, 144,145 and Wernickes encephalopathy 146

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