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has demonstrated that obesity increases the production of soluble UA mediated by gut dysbiosis, contributing to accelerating resorption of alveolar bone in periodontitis, which processes could be blocked by allopurinol, a xanthine oxidase inhibition (104)

Whereas water, lipid-soluble molecules, and some gases can pass through the blood-brain barrier via passive diffusion, molecules such as glucose and amino acids that are crucial to neural function enter via selective transport

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