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Significant improvements in waist circumference and multiple cardiometabolic risk factors

Graphical Abstract Similar content being viewed by others Introduction Bariatric surgery is the most effective therapy for severe obesity

Tsou SH, Luo KS, Huang CN, et al

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On 21 May 2026 , Lilly published the long-awaited topline results from the TRIUMPH-1 Phase 3 trial, and the data is striking: participants on the highest dose lost an average of 28.3% of their body weight at 80 weeks , with 45.3% of patients losing 30% or more a threshold previously only achievable with bariatric surgery