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GABA from reactive astrocytes impairs memory in mouse models of Alzheimers disease

A possible clue to their mechanism is provided by a trial with flumazenil (Anexate, Romazicon) a benzodiazepine receptor antagonist, published by Lader and Morton (Journal of Psychopharmacology 1992, 6, 357-63)

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Along with L-carnitine which is naturally created in the body, they are able to produce energy from body fat

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DAM release superoxide radicals (i.e., ROS), nitric oxides, and pro-inflammatory cytokines and factors (IL-1, TNF-, C1q), which induce neurotoxic C3 + reactive astrocytes (Liddelow et al., 2017)