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This review will provide insights into the latest research on the mechanisms and treatments of renal tubular injury in DKD

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The PERK-ATF4 pathway induces the expression of multiple vascular endothelial growth factors, including VEGFA, VEGFB, VEGFC, VEGFD, VEGFF, and placental growth factor, which collectively support endothelial cell survival, neovascularization, and sustained tumor growth

A complete course of treatment usually lasts between 3 to 6 months, during which the injections are taken regularly, as advised by a healthcare professional