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Microdosing titration with smaller dose increments Strategy B: Increase dosing frequency with reduced dose size This method involves administering smaller doses more frequently than once per week (e.g., every 34 days), which can help maintain more stable drug levels and potentially reduce side effects caused by peak concentrations

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Analytical workflows commonly combine reversed-phase LC separation, high-resolution mass spectrometry (HRMS), and tandem MS fragmentation to detect low-level impurities and structural modifications

The study also revealed an additional, unexpected benefit: Participants who smoked cigarettes also cut back on their tobacco use during the trial