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Interest in the relationship between UA and PD was sparked by an autopsy study in which postmortem UA levels in the substantia nigra and striatum were lower in patients with PD than in age-matched controls [87]

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The potential loss of essential homoeostatic astrocyte functions includes (i) down-regulation of glutamate uptake that disturbs circuit function and increases excitotoxic potential 141,142,143

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Higher dosing or longer cycles use more compounded medication