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Agonist-induced activation of G protein-coupled receptors (pharmacomechanical coupling): Agonists such as drugs, hormones and/or neurotransmittersfor example, carbachol (in airway and gastrointestinal smooth muscle), phenylephrine (in vascular smooth muscle), and oxytocin (in uterine smooth muscle)can trigger the phospholipase C 1 (PLC 1) pathway by activation of their receptors, caus-ing calcium release from the sarcoplasmic reticulum mediated by inositol 1,4,5-trisphosphate (IP 3 ) and, subsequently, an influx of these ions through Cav in the cell membrane, in processes called phasic and tonic contraction, respectivel (Figure 4)
These are usually limited to the injection site and settle quickly on their own
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Technical Specifications Class: Long-acting amylin analogue Appearance: White lyophilized powder Amount per Vial: See variants Handling & Storage Lyophilized powder: Store at -20C for long-term stability
