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29 GLP-1, an endocrine hormone, is secreted by enteroendocrine L-cells located in the distal jejunum, ileum, and colon in response to nutrient ingestion and neuroendocrine stimulation

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For example, SBP reductions were only 1.2 mmHg in the LEADER study and 1.7 mmHg in the REWIND study (54, 67), yet, the GLP-1RAmediated reduction in ASCVD reduction was comparable to that observed in the other CVOTs (48)

Such widespread usage has led to a severe and prolonged international shortage of these drugs 13,14 , with consequent lack of access to treatment for patients with diabetes 15 and the urgent need to issue guidelines for alternative treatments 16

Reusing needles : Always use a new needle for each injection to maintain sterility and minimize discomfort

Together, our results thus support the existence of a OB AON LH PVN circuit (Supplementary Fig