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This can only be partially attributed to weight loss [21] reported a weight-independent effect of GIP receptor stimulation on insulin sensitivity

Interestingly, evidence suggests a potential link between HFpEF and fatty liver disease as a dual-organ manifestation due to shared comorbidities (obesity, type 2 diabetes, hypertension, and hyperlipidemia) and underlying mechanisms (lipotoxicity, inflammation, and fibrosis) 79

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These systems maintain high steady-state concentrations of small-molecule antioxidants including reduced glutathione (GSH) and vitamin C (VitC)

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