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Does combining them make mechanistic sense

(81) functionally investigated the role of thioredoxin redox proteins ( Txdnc2 and Txdnc3 ) in mice to show that these genes limited oxidative stress ( P 40 years of age compared with those younger than 40 years of age, although a significant relationship between DNA fragmentation and increased paternal age was observed

This is consistent with the diminished hypertrophic response of mature or aged muscle to IGF-I, where there is a reduction in the pool of activated satellite cells compared to young, growing muscle 88

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