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5.3.6 ROS enhances autophagy-lysosomal system-mediated muscle structural disruption The autophagy-lysosomal pathway (ALP) is an essential intracellular degradation system that maintains proteostasis by eliminating dysfunctional organelles and aggregated proteins

2 Materials and methods 2.1 Reagents and biochemicals MK-2206 2HCl and finasteride (Fin) were purchased from Shanghai Selleck Chemicals Co., Ltd