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When you use sub-therapeutic doses (for example, 0.05 mg), the medication may not be as effective as standard doses, and you may not achieve adequate blood sugar control

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ATF4 activation upregulates GSH and dTTP pools in T315I-Bcr-Abl-32D cells Next, we want to address the questions of what causes the increases in dTTP and GSH biosynthesis in T315I-Bcr-Abl and whether blocking the upregulation of these two factors can increase JMF4073 sensitivity

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doi: 10.3389/fcimb.2017.00012 84 HoldenV