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Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats

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As you can see from the study above the dosages were quite high (up to 2,500mg per day) and most Doctors start patients on doses as low as 500mg per day and may never increase it from there

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