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Acknowledgements The study was supported by the National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program, National Tumor Biology Laboratory (grant 2022-2.1.1-NL-2022-00010 to P.N.)
Apr 2011;33(7):822-828
While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful
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