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Published by Cambridge University Press on behalf of The Nutrition Society Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent hepatic disorder worldwide and is estimated to afflict approximately 38 % of the worlds population, with an annual incidence of 4613 new cases per 1000 person-years (Reference Wai-Sun Wong, Ekstedt and Lai-Hung Wong1,Reference Le, Le and Baez2)

Heavy metals, such as lead, mercury, and cadmium, can deplete glutathione levels, impairing the body's ability to detoxify harmful substances and reducing the availability of SAMe for methylation

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