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It is worth noting that, abrupt discontinuation poses a risk of ICP rebound and symptom exacerbation [101], while the cognitive safety associated with chronic use remains underexplored [100]

First, it is based solely on in silico analyses, and the predicted interactions require experimental validation

doi: 10.3390/ijms141020845

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References Acin-Perez R, Beninc C, Fernandez del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S et al (2023) Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies

This step includes a complete review of any necessary lab work to support a holistic approach