Vallon V, Blantz RC, Thomson S
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The D-retro-inverso design replaces all L-amino acids with D-amino acids and reverses the sequence a structural strategy that preserves the side-chain topology of the original FOXO4 binding region while making the peptide resistant to proteolytic degradation, dramatically extending plasma half-life compared to the natural L-form
In addition DHLA may also be able to regenerate other endogenous antioxidants such as vitamins C and E, and has the beneficial property of neutralizing free radicals without itself becoming one in the process (Biewenga et al., Regeneration of other antioxidants When an antioxidant molecule reacts with an unstable free radical molecule, the antioxidant molecule itself becomes oxidized and loses its benefits until it is reduced again
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