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We observed an increase of pyruvate M + 3 and a decrease in citrate and malate M + 2 isotopologs in bTNF--treated bFLS, suggesting a decreased flow of glucose carbons into the TCA cycle and metabolic rewiring (Fig

In terms of side effects and tolerability, the advantage goes to Tirzepatide

Response: We thank the commenters for bringing this to our attention

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at the 20 mg/kg mouse dose, the human-equivalent dose would be approximately 1.6 mg/kg

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