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Our findings highlight the potential for clinical use of Cbi-Ex4 for millions of patients seeking improved glycemic control without common side effects (e.g., emesis) characteristic of current GLP-1 therapeutics.

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Testing can reveal whether a patient genetically favors dopamine-driven approaches (bupropion's strength) or gut-hormone-driven approaches (semaglutide's mechanism), helping clinicians design truly personalized dual therapy