Saxagliptin Add-On Combination Therapy with Metformin HCl plus Sulfonylurea A total of 257 patients with type 2 diabetes mellitus participated in this 24-week, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of saxagliptin in combination with metformin HCl plus a sulfonylurea in patients with inadequate glycemic control (A1C 7% and 10%)
Review contraindications against your own history: Medullary thyroid carcinoma family history, MEN 2 syndrome, pancreatitis history, severe GI or kidney disease, pregnancy, breastfeeding - if any of these apply, discuss with your own physician before starting the intake
Caution is advised when administering this injection to children under 18 years of age
Before starting any new medication, even something over-the-counter, you should speak with a licensed professional
While each peptide has an independent body of preclinical literature, no published peer-reviewed study has examined this specific combination, and the theoretical synergy between their complementary mechanisms remains unvalidated by controlled experimental evidence
PMC Article PMC4838773
