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The more common adverse effects include allergic reactions, stomach pain, diarrhea, constipation, nausea, and vomiting

Kidney markers, bicarbonate and oxidative stress should be interpreted alongside it

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Recently it has become apparent that immune dysregulation rather than an overactive immune response per se can play a significant role in disease pathology

Interestingly, inhibiting PDE4 (101, 102), PDE2A (103, 104), PDE4D (105, 106), or synergistically PDE2 and PDE4 (107) demonstrated beneficial effects in terms of rescue of social and behavioral impairments and in dendritic spines morphology in fly and mouse models

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