In a multicellular organism, TLs are highly heterogeneous across different tissues and cell types depending, at least partly, on the tissue-specific proliferation rate, but they generally tend to decrease with age in all proliferating tissues (Demanelis et al., The size of critically short (uncapped) telomeres may be stabilized by telomerase, a reverse transcriptase enzyme that can elongate chromosome ends de novo
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These peptides are known for their anti-inflammatory, antimicrobial, and antioxidant properties, effectively reducing inflammation, eliminating bacteria, and promoting tissue remodeling to minimize scar tissue
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10.1016/s0893-133x(01)00229-9 46 HsiehJ
This is partly attributed to KPVs entry through colonic cells via PepT1 channels, which are significantly expressed in the intestine primarily during states of inflammation
