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Key among his reckoning with political realities was a special election he called in November 2005, in which four ballot measures he sponsored were defeated

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EGCG downregulates M1 markers (IL-6, TNF-, and IL-1) and upregulates M2 markers (IL-10 and NQO1) in microglia, thereby modulating the M1/M2 ratio and mitigating neurotoxicity and neuronal damage arising from microglial hyperactivity (13)