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Titration schedule: Retatrutide's glucagon receptor activation provides an additional thermogenic effect absent from semaglutide and tirzepatide

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4,5,6 Since 2008, the Food and Drug Administration (FDA) and European Medicines Agency have required that new T2D pharmacotherapies undergo rigorous cardiovascular safety clinical trials using hard cardiovascular endpoints and more stringent statistical review

Psychiatry 26 , 43944408 (2021)