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Inspired by Nature, Engineered for Longevity: The Birth of GLP-1 Agonists The discovery of exendin-4 paved the way for the development of the first GLP-1 receptor agonist, exenatide (Byetta), which was directly derived from the Gila monster's venom

PMID: 22338093

At Novo Nordisk in Denmark, Lotte Bjerre Knudsen and colleagues utilised a technique already developed for prolongation of the action of insulin, viz

GLP-1 agonists like semaglutide have proven that harnessing this hormone alone can lead to significant weight loss (~15% on average)

Enhance insulin secretion Stimulates insulin release only when blood glucose is high

Telogen Effluvium Associated with Weight Loss: A Single Center Retrospective Study