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Freeze-drying, or lyophilization, removes water from the product by freezing it and drawing off the ice under vacuum, leaving a dry cake in the vial
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Gnocchi, D., Massimi, M., Alisi, A., Incerpi, S
Its main mechanism of action is based on increasing the expression of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptors in the hippocampus and prefrontal cortex, promoting synaptic plasticity, long-term potentiation (LTP), and memory consolidation (Dolotov et al., Neuroscience 2006)
Its investigation continues in research settings, but clinical applications remain experimental
USA 109 , 1533015335 (2012)
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