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For the Foetus Neural Tube Defects : Vitamin B12 deficiency during pregnancy can trigger neural tube defects in the unborn baby, which may affect his spinal cord and brain

The mice developed age-associated cataracts over time

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These warnings, as well as knowledge of the negative secondary ocular outcomes in the large diabetes clinical trials, likely play a role in the referrals to eye clinics for retinal examinations from internists