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Electrophoresis 19:18531861 Antoine DJ, Williams DP, Kipar A, Jenkins RE, Regan SL, Sathish JG, Kitteringham NR, Park BK (2009) High-mobility group box-1 protein and Keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
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GLUCOSE-DEPENDENT INSULIN STIMULATION (Pancreatic Beta Cells): Activates GLP-1 receptors on pancreatic beta cells stimulates insulin secretion ONLY when blood glucose is elevated This glucose-dependence is a critical safety advantage: minimal risk of hypoglycaemia (low blood sugar) when used alone Promotes beta cell proliferation and survival potentially preserving insulin-secreting capacity over time 2
