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The most concrete human evidence is concentrated in topical skin and specific wound-study contexts [2], [3], [8]
-Sitosterol selectively inhibits the activity of the pro-inflammatory mediator COX-2 and reduces the levels of the oncogenic PGE 2 in tumor tissues, blocking the promotion of tumor cell proliferation by the COX-2/PGE 2 inflammatory axis (92)
Prolonged use of certain creams (e.g., hydroquinone) can be harmful
The advantage of small molecules over peptides is generally better oral bioavailability, improved stability, lower manufacturing costs, and easier pharmaceutical development
A clustering of contamination events or persistent post-inflammatory hyperpigmentation cases tied to specific at-home protocols would shift the recommendation toward more conservative cadence or stricter contraindication screening